Abstract

Protein–protein interactions (PPIs) play important roles in various cellular processes and have become a major area in drug development. Most of the studies that are related to protein–protein interactions (PPIs) are correlated with different types of diseases, including infectious diseases, cancer, and neurodegenerative disorders. Therefore, targeting PPIs constitutes a therapeutic avenue for disease and an essential strategy for new drug development. In the last 10 years, PPI has been an emerging field in the study of drug intervention, and it’s the most difficult task for drug discovery. In recent years, most PPI modulators have not only been developed, but clinical trials have also been carried out on them for their potential to treat a particular disease. Those that have been approved from an industrial point of view have been suggested by the experts, as they have a broad future in drug discovery. In this study, we focus on summarizing recent advances in the field of PPI, including computational analysis, its types, detection methods, andfuture perspectives for the design of type new drugs targeting PPIs in the future.

Keywords: Protein–protein interactions, computational analysis, detection methods, future design, drug development

INTRODUCTION

Proteins are organic molecules and the building blocks of living organisms, composed of amino acids. Protein–protein interactions (PPIs) play an important role in various biological processes and are often identified as biomarkers in diseases. Targeting PPIs has gained significant attention in drug development [1]. PPIs are involved in many cellular pathways and are often altered in disease states.

Keyworde: Protein–protein interactions, computational analysis, detection methods, future design, drug development

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