Abstract

Nutrition plays a pivotal role in human health, encompassing a wide spectrum of nutrients crucial for bodily functions. Nutrients are typically divided into two categories: macronutrients and micronutrients, and people often use dietary supplements to augment their intake of these essential elements. However, the use of such supplements can have both benefits and risks, necessitating careful monitoring and prescription. This review highlights recent advancements in the monitoring of nutrients, with a focus on biomarkers, wearable devices, and artificial intelligence (AI). Biomarkers offer precise measurements of nutritional status, integrating dietary intake and biological responses. Wearable devices, including sweat sensors and electrochemical sensors, provide practical and portable solutions for real-time nutrient tracking. AI, coupled with big data, enhances nutritional assessment and personalized health management. Furthermore, the study emphasizes the importance of monitoring nutrients in specific populations, such as pregnant women and post- ariatric surgery patients, to prevent deficiencies and adverse effects. It also underscores the potential benefits of AI in healthcare but stresses the need for ethical considerations. In conclusion, advancements in nutrient monitoring through biomarkers, wearable devices, and AI have the potential to revolutionize healthcare and nutrition. These technologies offer the promise of personalized dietary guidance and improved health outcomes, provided that ethical and policy considerations are prioritized.
Keywords: Precision nutrition, wearable biosensors, artificial intelligence in healthcare, nutritional
monitoring technology, metabolic and nutritional analysis
INTRODUCTION
Nutrients
Nutrients are fundamental compounds necessary for the body’s growth, development, and
sustenance. These essential substances are sourced from food and are needed in diverse quantities to facilitate various bodily functions. Nutrients are categorized into two primary groups: macronutrients and micronutrients. Macronutrients are necessitated in substantial quantities and encompass carbohydrates, proteins, and fats. Micronutrients, on the other hand, are required in smaller quantities and consist of vitamins and minerals.

Keyworde: Precision nutrition, wearable biosensors, artificial intelligence in healthcare, nutritional monitoring technology, metabolic and nutritional analysis

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Refrences:

1. Regional Committee for Africa, 28. (1978). Noting the measures taken by the Regional Director to
implement resolution AFR/RC27/R14 on the importance of nutrition in socioeconomic
development. [online] World Health Organization. Regional Office for Africa. Available from:
https://iris.who.int/handle/10665/103280
2. Sajid MR, Quraiba LN, Khames RI, AlHusseini NK, Alsheikh H, Basha NR, et al. Frequency of
dietary supplements usage in the Saudi Arabian public and gym users. J Contemp Med Sci. 2020
Nov 1;6(6):300–5. doi: 10.22317/jcms.v6i6.886.
3. Holeček M. Side effects of amino acid supplements. Physiol Res. 2022 Feb;71(1):29–45. doi:
10.33549/physiolres.934790.
4. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of
ovulatory disorder infertility. Obstet Gynecol. 2007 Nov 1;110(5):1050–8. doi:
10.1097/01.AOG.0000287293.25465.e1.
5. Hu S, Lin S, Feng Q, He X, Xu H, Chen L et al. Iron complexes with Antarctic krill–derived
peptides show superior effectiveness to their original protein–iron complexes in mice with iron
deficiency anemia. Nutrients. 2023 May 28;15(11):2510. doi: 10.3390/nu15112510.
6. National Institutes of Health. (2019). Office of Dietary Supplements – Multivitamin/mineral
Supplements. [online] nih.gov. Available from: https://ods.od.nih.gov/factsheets/MVMSHealthProfessional/
7. U.S. Food and Drug Administration. (2022). FDA 101: Dietary Supplements. [online] U.S. Food
and Drug Administration. Available from: https://www.fda.gov/consumers/consumer-updates/fda101-dietary-supplements
8. National Institutes of Health. (2023). Office of Dietary Supplements – Dietary Supplements: What
You Need to Know. [online] nih.gov. Available from: https://ods.od.nih.gov/factsheets/WYNTKConsumer/.
9. Johns Hopkins School of Medicine. (2019). Dietary Supplements. [online] hopkinsmedicine.org.
Available from: https://www.hopkinsmedicine.org/health/wellness-and-prevention/dietarysupplements
10. US Preventive Services Task Force, Mangione CM, Barry MJ, Nicholson WK, Cabana M,
Chelmow D, et al. Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular
disease and cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2022
Jun 21;327(23):2326–33. doi: 10.1001/jama.2022.8970.
11. Sarris J, Mehta B, Óvári V, Ferreres Giménez I. Potential mental and physical benefits of
supplementation with a high-dose, B-complex multivitamin/mineral supplement: what is the
evidence? Nutr Hosp. 2021 Dec 1;38(6):1277–86. doi: 10.20960/nh.03631.
12. Fantacone ML, Lowry MB, Uesugi SL, Michels AJ, Choi J, Leonard SW et al. The effect of a
multivitamin and mineral supplement on immune function in healthy older adults: a double-blind,
randomized, controlled trial. Nutrients. 2020 Aug 14;12(8):2447. doi: 10.3390/nu12082447.
13. Greenberg JA, Bell SJ. Multivitamin supplementation during pregnancy: emphasis on folic acid
and l-methylfolate. Rev Obstet Gynecol. 2011;4(3–4):126–7.
14. Elmore C, Ellis J. Screening, treatment, and monitoring of iron deficiency anemia in pregnancy and
postpartum. J Midwifery Womens Health. 2022 May;67(3):321–31. doi: 10.1111/jmwh.13370.
15. Dobbin M, Liew DF. Real-time prescription monitoring: helping people at risk of harm. Aust
Prescr. 2020 Oct;43(5):164–7. doi: 10.18773/austprescr.2020.050.
16. Ronis MJJ, Pedersen KB, Watt J. Adverse effects of nutraceuticals and dietary supplements. Annu
Rev Pharmacol Toxicol. 2018 Jan 6;58:583–601. doi: 10.1146/annurev-pharmtox-010617-052844.
17. U.S. FDA. (2023). Dietary Supplements. [online] U.S. Food and Drug Administration. Available
from: https://www.fda.gov/food/dietary-supplements.
18. Consumer Reports, Inc. (2023). Dangers of Vitamins and Supplements. [online] Consumerreports.
org. Available from: https://www.consumerreports.org/cro/magazine/2012/09/10-surprisingdangers-of-vitamins-and-supplements/index.htm
19. Wadyka S. (Sep 13, 2023). Immune-Boosting Foods That Help Keep You Well. [online] Consumer
Reports. Available from: https://www.consumerreports.org/health/nutrition-healthy-eating/immuneboosting-foods-that-help-keep-you-well-a4816367434/
20. Lacey K, Pritchett E. Nutrition care process and model: ADA adopts road map to quality care and
outcomes management. J Am Diet Assoc. 2003;103(8):1061–72. doi: 10.1016/s0002-
8223(03)00971-4.
21. Hess CT. Monitoring laboratory values: transferrin, C-reactive protein, erythrocyte sedimentation
rate, and liver function. Adv Skin Wound Care. 2009 Feb 1;22(2):96. doi: 10.1097/01.ASW.00003
45287.28403.76.
22. Strain JJ, Cashman KD. Minerals and trace elements. Introduction Hum Nutr. 2009 Nov 24;188.
23. Singh M. Role of micronutrients for physical growth and mental development. Indian J Pediatr.
2004 Jan;71(1):59–62. doi: 10.1007/BF02725658.
24. Rocha MS, Ribas Filho D. Nutrological management in bariatric surgery: A narrative review.
MedNEXT. 2021 Jun 9;2(3):6–12. doi: 10.34256/mdnt2132.
25. Picó C, Serra F, Rodríguez AM, Keijer J, Palou A. Biomarkers of nutrition and health: new tools
for new approaches. Nutrients. 2019 May 16;11(5):1092. doi: 10.3390/nu11051092.
26. Yin S, Yang Y, Wu L, Li Y, Sun C. Recent advances in sample preparation and analysis methods
for vitamin D and its analogues in different matrices. TrAC Trends Anal Chem. 2019 Jan
1;110:204–20. doi: 10.1016/j.trac.2018.11.008.
27. Ishida J, Kato A. Recent advances in the nutritional screening, assessment, and treatment of Japanese
patients on hemodialysis. J Clin Med. 2023 Mar 8;12(6):2113. doi: 10.3390/jcm12062113.
28. Natalucci V, Marmondi F, Biraghi M, Bonato M. The effectiveness of wearable devices in noncommunicable diseases to manage physical activity and nutrition: where we are? Nutrients. 2023
Feb 11;15(4):913. doi: 10.3390/nu15040913.
29. Del Caño R, Saha T, Moonla C, De la Paz E, Wang J. Ketone bodies detection: wearable and mobile
sensors for personalized medicine and nutrition. TrAC Trends Anal Chem. 2023 Jan
13;159:116938. doi: 10.1016/j.trac.2023.116938.
30. Jayadev Calamur. (2016). This device claims to accurately measure your vitamin and mineral
levels. [online] DNA India. Available from: https://www.dnaindia.com/technology/report-thisdevice-claims-to-accurately-measure-your-vitamin-and-mineral-levels-2251237.
31. Huey SL, Krisher JT, Morgan D, Mkambula P, Srinivasan B, Gannon BM, et al. Portable devices
for measurement of vitamin A concentrations in edible oil: field readiness of available options. ACS
Omega. 2022 May 17;7(21):17502–18. doi: 10.1021/acsomega.1c07181.
32. Romero-Tapiador S, Lacruz-Pleguezuelos B, Tolosana R, Freixer G, Daza R, Fernández-Díaz CM
et al. AI4FoodDB: a database for personalized e-health nutrition and lifestyle through wearable
devices and artificial intelligence. Database (Oxford). 2023 Jan 1;2023:baad049. doi: 10.1093/data
base/baad049.
33. Zhu C, Bing Y, Chen Q, Pang B, Li J, Zhang T. Nonenzymatic flexible wearable biosensors for
vitamin C monitoring in sweat. ACS Appl Mater Interfaces. 2023 Apr 10;15(15):19384–92. doi:
10.1021/acsami.2c22345.
34. Mukasa D, Wang M, Min J, Yang Y, Solomon SA, Han H et al. A computationally assisted
approach for designing wearable biosensors toward non‐invasive personalized molecular analysis.
Adv Mater. 2023 May 9;35(35):e2212161. doi: 10.1002/adma.202212161.
35. Mortazavi BJ, Gutierrez-Osuna R. A review of digital innovations for diet monitoring and precision
nutrition. J Diabetes Sci Technol. 2023 Jan;17(1):217–23. doi: 10.1177/19322968211041356.
36. Wang WH, Hsu WS. Integrating artificial intelligence and wearable IoT system in long-term care
environments. Sensors (Basel). 2023 Jun 26;23(13):5913. doi: 10.3390/s23135913.
37. Bond A, Mccay K, Lal S. Artificial Intelligence & Clinical Nutrition: what the future might have
in store. Clin Nutr ESPEN. 2023 Jul 22;57:542–9. doi: 10.1016/j.clnesp.2023.07.082.
38. Kelly JT, Jegatheesan DK, Dawson J, Barnett A, Khor BH, Chang AR, et al. Are digital health
technologies and models of nutrition care the future of chronic kidney disease management? J Ren
Nutr. 2023 Mar 24;33(6S):S80–7. doi: 10.1053/j.jrn.2023.02.004.
39. Joshi S, Bisht B, Kumar V, Singh N, Jameel Pasha SB, Singh N, et al. Artificial intelligence assisted
food science and nutrition perspective for smart nutrition research and healthcare. Syst Microbiol
Biomanufacturing. 2023 Aug 9:1–6. doi: 10.1007/s43393-023-00200-4.
40. Ruiz-Valdepeñas Montiel VR, Sempionatto JR, Vargas E, Bailey E, May J, Bulbarello A et al.
Decentralized vitamin C & D dual biosensor chip: toward personalized immune system support.
Biosens Bioelectron. 2021 Dec 15;194:113590. doi: 10.1016/j.bios.2021.113590.
41. Wang M, Yang Y, Min J, Song Y, Tu J, Mukasa D, et al. A wearable electrochemical biosensor for
the monitoring of metabolites and nutrients. Nat Biomed Eng. 2022 Nov;6(11):1225–35. doi:
10.1038/s41551-022-00916-z.